NFL Week 1 Picks: Best Bets From A Vegas Expert For The roster cuts are all behind us as we head into the games that matter for Week 1 of on the board at a virtual pick 'em when you erase the 3- point home bump. Follow our live coverage of N.F.L. Week 1 here. pick is not necessarily the winner of the game, but would be a winning bet based on the point spread. Top -tier games Credit Tim Heitman/ USA Today Sports, via Reuters. NFL odds , Week 1: Betting lines, trends, and analysis for the week's top games Stew Milne- USA TODAY Sports Kansas City lost that game, , as a six- point underdog in New England. For more info, picks and a breakdown of this week's top sports betting news check out the new OddsShark.